2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101619
    Abaperidone 183849-43-6 98%
    Abaperidone is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM.
    Abaperidone
  • HY-101629
    (E)-Crotylbarbital 28360-89-6 98%
    (E)-Crotylbarbital is the isomer of Crotylbarbital. Crotylbarbital is a barbiturate derivative and can be used for the research of insomnia.
    (E)-Crotylbarbital
  • HY-101632
    Irindalone 96478-43-2 98%
    Irindalone is a novel serotonin 5-HT2 antagonist.
    Irindalone
  • HY-101635
    Proxibarbal 2537-29-3 98%
    Proxibarbal is a barbiturate derivative. Proxibarbal has anti-anxiety properties and is also used for the study of migraine headaches.
    Proxibarbal
  • HY-101641
    NRA-0160 204718-47-8 98%
    NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM).
    NRA-0160
  • HY-101658
    Pargolol hydrochloride 36902-82-6 98%
    Pargolol hydrochloride is a β adrenergic receptor antagonist. Pargolol hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Pargolol hydrochloride
  • HY-101669
    TDN345 134069-68-4 98%
    TDN345 is a Ca2+ antagonist, used for the treatment of vascular and senile dementia including Alzheimer's disease.
    TDN345
  • HY-101684
    Nitroxazepine 47439-36-1 98%
    Nitroxazepine is a tricyclic antidepressant (TCA) for the research of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor.
    Nitroxazepine
  • HY-101698
    Alniditan 152317-89-0 98%
    Alniditan (Alnitidan) is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan has migraine-preventive effects.
    Alniditan
  • HY-101747
    ADR 851 free base 138559-56-5 98%
    ADR 851 free base is a dopamine D2 receptor antagonist,and can be used in research on antiemetics.
    ADR 851 free base
  • HY-101754
    Oxyfenamate 50-19-1 98%
    Oxyfenamate has anti-anxiety actions for use in anxiety neuroses.
    Oxyfenamate
  • HY-101817
    Spirendolol 81840-58-6 98%
    Spirendolol is a β adrenergic receptor antagonist.
    Spirendolol
  • HY-101827
    Citenamide 10423-37-7 98%
    Citenamide is an anticonvulsant.
    Citenamide
  • HY-10232R
    THIP (Standard) 64603-91-4 98%
    THIP (Standard) is the analytical standard of THIP. This product is intended for research and analytical applications. THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC50 value of 13 μM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders.
    THIP (Standard)
  • HY-10232S
    THIP-d4 2748778-97-2 98%
    THIP-d4 (Gaboxadol-d4) is the deuterium labeled THIP (HY-10232). THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC50 value of 13 μM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders.
    THIP-d4
  • HY-10233R
    Gaboxadol hydrochloride (Standard) 85118-33-8 98%
    Gaboxadol (hydrochloride) (Standard) is the analytical standard of Gaboxadol (hydrochloride). This product is intended for research and analytical applications. Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 μM, a full agonist efficacy at α5 subunit (ED50=28-129 μM) and a superagonist efficacy at α4β3δ (ED50=6 μM). Gaboxadol hydrochloride is a non-opioid agent.
    Gaboxadol hydrochloride (Standard)
  • HY-10295R
    SB 202190 (Standard) 152121-30-7 98%
    SB 202190 (Standard) is the analytical standard of SB 202190. This product is intended for research and analytical applications. SB 202190 is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 has anti-cancer activity and rescued memory deficits. SB202190 induces autophagy.
    SB 202190 (Standard)
  • HY-103143
    SDZ 205-557 hydrochloride 1197334-02-3 98%
    SDZ 205-557 hydrochloride is a selective 5-HT4 receptors antagonist. SDZ 205-557 hydrochloride can be used for neurological research.
    SDZ 205-557 hydrochloride
  • HY-103163
    (±)-5'-Chloro-5'-deoxy-ENBA 103626-26-2 98%
    (±)-5'-Chloro-5'-deoxy-ENBA is an agonist of A1AR. (±)-5'-Chloro-5'-deoxy-ENBA produces hypothermia in mice.
    (±)-5'-Chloro-5'-deoxy-ENBA
  • HY-103168
    XCC 96865-83-7 98%
    XCC, 1,3,8-substituted xanthine derivative, is an adenosine receptor antagonist with Ki of 1.905 μM[1].
    XCC
Cat. No. Product Name / Synonyms Application Reactivity